Cochrane Database Syst Rev. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Prostate-specific natural health products (dietary supplements) radiosensitize normal prostate cells. Red clover has also been contraindicated with heparin, ticlopidine, and warfarin, based on its coumadin content. General information: If you have any questions about red clover leaf extract, please talk with your doctor, pharmacist, or other health care provider.  Further research is needed to determine the safety and efficacy of this agent. 2002;42:187-93. Red clover is a wild plant belonging to the legume family. Its active ingredients include phytoestrogens. Biochanin A protects dopaminergic neurons against lipopolysaccharide-induced damage through inhibition of microglia activation and proinflammatory factors generation. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Red Clover is not suitable for patients with hormone diseases such as breast, uterine, ovarian cancer or endometriosis. There is no evidence that red clover can help treat cancer. Those with hormone-sensitive conditions, such as breast cancer, ovarian cancer, or endometriosis,... Drug interactions. Red clover is effectively treats menopausal symptoms and irregular menses. Red clover: Red clover has been hailed as "the" herb for cancer by many herbalists. Was this article helpful? In red clover blossoms, the compounds biochanin-A, caffeic acid, chlorogenic acid, coumarin, formononetin, genistein and isorhamnetin all demonstrate some anti-cancer … The phytoestrogenic properties of the isoflavones in red clover are why it is not recommended for use by women who’ve been diagnosed with breast cancer, without first discussing it with their physician. Therefore, patients with estrogen receptor-positive cancers or undergoing radiotherapy for prostate cancer should avoid using red clover. Red clover contains substances called isoflavones. Now before going any further, I know that some of you object to using a phytoestrogen for prostate cancer. Le Bail JC, Champavier Y, Chulia AJ, Habrioux G. Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells. and anti-osteoporotic effects, as well as for their ability to relieve menopausal symptoms. Donate today. The effects of phytoestrogen isoflavones on bone density in women: a double-blind, randomized, placebo-controlled trial. Red Clover is one of the ingredients s of the ‘controversial Hoxsey cancer treatment,’ developed by Harry Hoxsey in the 1920’s. An isoflavone extract is widely promoted as a dietary supplement to relieve menopausal symptoms. Red clover does not seem to reduce menopausal symptoms. An isoflavone-enriched fraction showed neuroprotective activity in human cortical neurons as well, possibly due to antioxidant and estrogenic effects (4). Isoflavones are effective in treating several conditions such as hot flashes, cardivascular health and osteporosis. Her symptoms resolved after discontinuation of the supplement.. 11. Studies suggest it is not effective in treating hot flashes. Overview. In vivo prediction of CYP-mediated metabolic interaction potential of formononetin and biochanin A using in vitro human and rat CYP450 inhibition data. Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial. Any questions regarding your own health should be addressed to your own physician or other healthcare provider. Red clover contains isoflavone compounds similar to those found in soy. Red clover is used in Turkish folk medicine as expectorant, antiseptic, analgesic properties and as a treatment for rheumatic aches. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Red clover leaf extract is to be used only by the patient for whom it is prescribed. Red Clover’s Anti-Cancer Effects Red clover contains a weak phytoestrogen called formononetin. Red clover has long been used as a “blood purifier,” specifically for the potential treatment of cancer. The herb has tumor-inhibiting properties and strengthens lymphatic functions (crucial in cleansing cell tissues). Although red clover isoflavones show hormonal activity in laboratory experiments, their effects in the human body are less clear. Cattle and other animals graze on red clover. 2004;79:326-33. The folk healers of Russia used Red clover to treat asthma. The chemical and biologic profile of a red clover (, Long-term pharmacokinetics of an extract of isoflavones from red clover (. The treatment of cancer with Red Clover has a great many advocates and has been with us for a long time. Red clover is used to treat cancer as well as respiratory problems such as asthma, whooping cough and bronchitis. Symptoms resolved after supplement discontinuation (16). -Barrie Cassileth, PhD. Red Clover Kills Prostate Cancer Cells By Michael A. Smith, MD More than 238,000 men will be diagnosed with prostate cancer in the United States, and nearly 30,000 will die from it. The relation between red clover and cancer is not been fully discovered yet. Red clover is a perennial herb traditionally used to treat skin conditions such as eczema and psoriasis, whooping cough, and respiratory problems. Red clover extracts (RCE) are rich in isoflavones, particularly genistein and daidzein and they have been proved to be effective in reducing vasomotor symptoms in a number of studies. Red clover (Trifolium pratense) is a medicinal herb containing flavonoids, coumarins, coumestans, and isoflavones. 7. It’s used to make an herbal supplement that may have some immune-boosting and positive hormonal effects, especially for postmenopausal women. Red clover contains substances called isoflavones. This Web site is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. All rights reserved. Formononetin-induced apoptosis by activation of Ras/p38 mitogen-activated protein kinase in estrogen receptor-positive human breast cancer cells. Red clover extract can stimulate the production of estrogen receptor-positive breast cancer cells in lab experiments. Hasan Y, Schoenherr D, Martinez AA, et al. 2007(4):CD001395. As I indicated above, this is not likely to produce sufficient results. If your symptoms do not improve or if they become worse, contact your doctor or pharmacist as soon as possible. Cattle and other animals graze on red clover. 10. Two: This is often used for children that have a persistent, bad cough. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. 1 In fact, about one in six men will be diagnosed with this condition during their lifetime. A meta-analysis of a standardized extract suggests potential reductions in total cholesterol in peri- and postmenopausal women, but studies were heterogeneous (29). In red clover blossoms, the compounds biochanin-A, caffeic acid, chlorogenic acid, coumarin, formononetin, genistein and isorhamnetin all demonstrate some anti-cancer … Comme vous le savez probablement, ces thérapies médicamenteuses font l'objet de discussions multiples aujourd'hui, car elles sont associées à une augmentation du risque de cancer du sein. Red clover contains compounds known as isoflavones that act as phytoestrogens. In one case, the issue resolved after supplement discontinuation. Int J Radiat Oncol Biol Phys. ALSO KNOWN AS: Cow clover, wild clover, purple clover, beebread, cow grass, meadow clover, purple clover. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. 6. Russian folk healers and traditional Chinese physicians have long used Red Clover for asthma, bronchitis and to clear the lungs. BCA has been reported to prevent various cancers including prostate, breast, and colon cancer. 1999;84:895-98. Red clover extract can stimulate the production of estrogen receptor-positive breast cancer cells in lab experiments. Cancer: Red clover has been studied for its ability to inhibit the growth of new blood vessels to tumours. Your generosity makes this possible. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. The isoflavones present in red clover have estrogen-like effects and have been the subject of intense research over the last decade. Isoflavones are phytoestrogens—compounds similar to the female hormone estrogen. Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models View ORCID Profile Aurelie de Rus Jacquet , Abeje Ambaw , View ORCID Profile Mitali A Tambe , Michael Timmers , Sin Ying Ma , Qing-Li Wu , James E Simon , George P McCabe , Mary Ann Lila , Riyi Shi , View ORCID Profile Jean-Christophe Rochet Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells. Regardless of the myths and folktales surrounding red clover, one thing has been proven through time - the herb makes a powerful addition to your natural medicine arsenal. Phytoestrogens for vasomotor menopausal symptoms. The loss of elasticity can contribute to increased blood pressure, causing the heart to work harder. Altern Ther Health Med. Red clover is a wild plant belonging to the legume family. Dried red clover flowers have been used in traditional medicine to treat a wide variety of ailments, including jaundice, cancer, breast tissue infections, joint disorders, and respiratory conditions (e.g, whooping cough, bronchial asthma), and as a sedative. Acute-on-chronic subdural hematoma in a patient taking Red Clover herbal supplement: A case report. Epub 2011 May 26. Gynecol Endocrinol. Due to their partial selectivity of action on estrogen receptors (ERs) these compounds have been claimed to … Among classic herbalists, red clover is known as one of the world’s oldest and most common natural herbal supports for the treatment for all varieties of cancer — anywhere in the body. Like peas and beans, red clover belongs to the family of plants called legumes. In addition, here is an article from the Mayo Clinic mentioning how isoflavones in food such as soy are not sufficient to cause breast cancer, and in fact a lifelong diet including such foods actually reduces breast cancer: Read the article from the Mayo Clinic (Red clover is an herb, which is considered a food). 2000;66:1281-91. 2012 Jan;28(1):29-33. doi: 10.3109/09513590.2011.579660. Also known as: Daidzein, genistein, isoflavone, phytoestrogen, purple clover, trefoil, trifolium, beebread, clovone. It has also been used medicinally to treat several conditions including cancer, whooping cough, respiratory problems, and skin inflammations, such as psoriasis and eczema. Si vous êtes en période de ménopause, vous avez peut-être envisagé les thérapies hormonales afin de réduire les symptômes les plus gênants. Overuse of isoflavone supplements can increase the risk of hormone-sensitive cancer. Three: Blood flow seems to be enhanced by this herb since it can help prevent blood clots and thins the blood. Red clover has similar effects to estrogen and could complicate these conditions and interfere with treatment. Isoflavones may also improve bone loss (11). However, unless red clover herb is fermented, it is unexpected to have any anticoagulant effects. Users of this Web site should not rely on information provided on this Web site for their own health problems. Studies on whether red clover may help reduce menopausal symptoms are mixed, and additional study is needed to confirm positive effects and safety with long-term use. Cattle and other animals graze on red clover. It’s possible that this herb may complicate these conditions and interfere with treatments, or even worse potentially raise the risk for them developing in the first place. In postmenopausal women, endometrial status was not adversely affected. While historically the RC plant has been taken in the form of tea and tinctures, today it’s often used to make extracts, such as the products … An increase in density is associated with a higher risk of breast cancer, inferring that … Red clover isoflavones are safe and well tolerated in women with a family history of breast cancer. 3. van de Weijer PH, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Isoflavone-enriched extracts have shown neuroprotective effects in human cortical neurons (3) (4) and reduced skin aging in mice by increasing collagen (5). Cuts down on the risk of breast cancer. Whilst there have been some very preliminary scientific studies to support the anti-cancer properties of Red Clover the evidence throughout the ages, like virtually all of our herbal lore, has been gathered through experience and observation. Not only does red clover and cancer treat cancer but also … Bleeding around the brain or skull: Related to herbal supplements containing red clover used for menopausal symptoms. Nestel PJ, Pomeroy S, Kay S, et al. It has also been used medicinally to treat several conditions including cancer, whooping cough, respiratory problems, and skin inflammations, such as psoriasis and eczema. Red clover (Trifolium pratense L.) is a plant in the Fabaceae botanical family. Until definitive data are available, patients should avoid use of red clover during radiotherapy for prostate cancer. In another, the patient required intensive medical interventions to resolve issues. Recent findings from a preclinical study suggest that red clover may increase resistance of prostate cancer cells to high-dose radiation while inhibiting the growth of normal prostate cells. The isoflavone Biochanin A inhibited activity and gene expression of aromatase, an enzyme that catalyzes the conversion of androgen to estrogen (2). Isoflavones are phytoestrogens—compounds similar to the female hormone estrogen. This Web site — Information About Herbs, Botanicals and Other Products — is for general health information only. Data on red clover’s potential for reducing the symptoms of menopause and for decreasing the risk of breast cancer are inconclusive. Red Clover for Bigger Breast – Side Effects. Red clover contains substances called isoflavones. I say this because a lot of women are simply going to think that red clover is completely safe. The herb has tumor-inhibiting properties and strengthens lymphatic functions (crucial in cleansing cell tissues). Red clover may help reduce menopausal symptoms, but additional study is needed. However, its usage in many parts of the world as a traditional cancer remedy has prompted scientists to take a close look at the herb. Red clover extracts (RCE) are rich in isoflavones, particularly genistein and daidzein and they have been proved t … Effects of red clover extracts on breast cancer cell migration and invasion Gynecol Endocrinol. Use of this Web site does not create an expressed or implied physician-patient relationship. It contains compounds known as isoflavones that act as phytoestrogens. Red clover is used in the treatment of skin complaints (especially eczema and psoriasis), cancers of the breast, ovaries and lymphatic system, chronic degenerative diseases, gout, whooping cough and dry coughs. The treatment of cancer with Red Clover has a great many advocates and has been with us for a long time. Red clover leaf extract may decrease the effectiveness of your birth control pill. An increase in density is associated with a higher risk of breast cancer, inferring that taking red clover could prove to … Red clover is one of the richest sources of isoflavones. Data on red clover’s potential for reducing the symptoms of menopause and for decreasing the risk of breast cancer are inconclusive. Red clover may also block enzymes thought to contribute to prostate cancer in men. Red clover has been claimed to be effective for treating hormonally driven cancers and for reducing hot flashes in women who experience premature menopause as part of their cancer treatment. Red Clover Basics. In vitro, red clover extract acts as an estrogen agonist and stimulates proliferation of estrogen receptor–positive breast cancer cells. The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women. Compounds in red clover include phytoestrogenic isoflavones such as genistein, diadzen, formononetin and biochanin A. In addition, it protected dopaminergic neurons against lipopolysaccharide-induced damage by inhibiting microglial activation and proinflammatory factors (3). Numerous studies have shown extracts of red clover to be safe and effective for hot flashes in particular. Coon JT, Pittler MH, Ernst E. Trifolium pratense isoflavones in the treatment of menopausal hot flushes: a systematic review and meta-analysis. No one with a hormone sensitive condition such as uterine cancer, breast cancer, ovarian cancer, uterine fibroids, or endometriosis, should use red clover. In a trial involving osteopenic postmenopausal women, a red clover extract rich in isoflavones, aglycones, and probiotics attenuated bone mineral density loss caused by estrogen deficiency and improved bone turnover (26). Historically, red clover was used for asthma, whooping cough, cancer, and gout. Life Sci. Am J Clin Nutr. Because red clover contains isoflavones that mimic the effects of the hormone estrogen once they enter the body, the safety of RC in patients with breast or endometrial cancer remains controversial. The formula was developed after his grandfather observed what sick horses grazed on to restore their health. Red Clover Uses. 2007;14:153-59. Red clover is a perennial herb traditionally used to treat skin conditions such as eczema and psoriasis, whooping cough, and respiratory problems. Clinical effects of a proprietary combination isoflavone nutritional supplement in menopausal women: a pilot trial. However, unless red clover herb is fermented, it is unexpected to have any anticoagulant effects. 9. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. Well, this can be dangerous, both for your breast and your liver! Red clover does not significantly reduce total or LDL cholesterol, or increase HDL in women 49-65. Potential interactions between alternative therapies and warfarin. The June 2004 edition of Breast Cancer Research states that red clover does not cause any oestrogenic increase in breast density, while human and synthetic oestrogen does. Usual dose: To relieve hot flashes, an extract of 40 to 160 milligrams per day has been used. Patients should consult with their physicians before taking red clover supplements.