Intravenous bolus injection administration. However, it will not treat a viral infection. The identification and antimicrobial susceptibility tests on any such isolate must be repeated and if the result is confirmed the isolate sent to a reference laboratory. What preparations of meropenem-injection are available? Meropenem injection ip 1g, stockiest and super stockiest (distributor) in the field of tablets, syrup, otc, antibiotics, life saving and critical care products. There are no established dose recommendations for patients receiving peritoneal dialysis. Meropenem may be used in the management of neutropenic patients with fever that is suspected to be due to a bacterial infection. Meropenem 500mg powder for solution for injection or infusion Meropenem 1g powder for solution for injection or infusion meropenem Read all of this leaflet carefully before you start taking this medicine. Generic Manufacturers wait for the patents to end and capitalize on the markets by producing bio-equivalent versions of the brand name drugs. The IV LD50 of meropenem in rodents is greater than 2000 mg/kg. Additional Information: There are limited safety data available to support the administration of a 2 g dose in adults as an intravenous bolus injection. Find dosages, compare prices and get up to 20% off on prescription medicines. Merolan is used to treat severe infections of the skin or stomach. The AUC of the microbiologically inactive ring opened metabolite was also considerably increased in patients with renal impairment. Keeping the diverse requirements of our clients in mind, we are engaged in distributing Meropenem Injection IP 1g.The offered injection is used in the treatment of several serious bacterial infections of various body parts like skin and soft tissues, urinary tract, blood, brain and … BiotransformationMeropenem is metabolised by hydrolysis of the beta-lactam ring generating a microbiologically inactive metabolite. Pharmacokinetic studies in healthy elderly subjects (65-80 years) have shown a reduction in plasma clearance, which correlated with age-associated reduction in creatinine clearance, and a smaller reduction in non-renal clearance. Meropenem will be given to you as an injection or infusion into a large vein. Meropenem 500 MG Injection is a broad spectrum antibiotic used to treat a variety of conditions caused by bacteria such as infections of stomach, brain, and lungs. The risk may vary with the underlying infection, age and general status of the patient so that the contribution of the antibiotic to the increase in INR (international normalized ratio) is difficult to assess. The potential effect of meropenem on the protein binding of other medicinal products or metabolism has not been studied. The most commonly reported meropenem-related laboratory adverse events were thrombocytosis (1.6 %) and increased hepatic enzymes (1.5-4.3 %). In vitro meropenem shows reduced susceptibility to hydrolysis by human dehydropeptidase-I (DHP-I) compared to imipenem and there is no requirement to co-administer a DHP-I inhibitor. Before starting treatment with this medicine, you should tell your doctor if you have epilepsy, liver or kidney problems or if you are allergic to any antibiotic. c) Each vial contains: Meropenem Trihydrate equivalent to Meropenem 500mg Excipients q.s. Meropenem 500mg / 1g Vials by UNITED BIOTECH (P) LTD, Manufacturer, Supplier, Exporter of Meropenem Injection IP 500mg / 1g Vials, Meropenem Injection etc. Direct antiglobulin test (Coombs test) seroconversion. Therefore, your doctor will decide whether you should use meropenem while breast-feeding. The identification and antimicrobial susceptibility tests on any such isolate must be repeated and if the result is confirmed the isolate sent to a reference laboratory. Until there is evidence regarding clinical response for confirmed isolates with MIC values above the current resistant breakpoint they should be reported resistant. The solution should be shaken before use. In the table below all adverse reactions are listed by system organ class and frequency: very common (≥ 1/10); common (≥ 1/100 to <1/10); uncommon (≥ 1/1,000 to <1/100); rare (≥ 1/10,000 to <1/1,000); very rare (< 1/10,000) and not known (cannot be estimated from the available data). It is not known whether Merokem 1 gm Injection alters the ability to drive. Meropenem exerts its bactericidal activity by inhibiting bacterial cell wall synthesis in Gram-positive and Gram-negative bacteria through binding to penicillin-binding proteins (PBPs). Lung and bronchial infections in patients suffering from cystic fibrosis. This is because Meropenem can affect the way some medicines work and some medicines can have an effect on Meropenem. A solution for infusion is prepared by dissolving the drug product meropenem in either 0.9% sodium chloride solution for infusion or 5% glucose (dextrose) solution for infusion to a final concentration of 1 to 20 mg/ml. Wholesaler of Meropenem Injections - Merotrol Injection, Meroza IV Injection, Humog-150 HP Injection and Merolan Injection offered by Patel Medisales ( A Unit Of Rajshree Medicals ), Bengaluru, Karnataka. Always use Meropenem exactly as your doctor has told you. Meronem (1 gm) 1gm - 1 Vial Injection (Meropenem) drug information. Date of first authorisation/renewal of the authorisation. Children from 3 months to 11 years of age and up to 50 kg body weight. penicillins or cephalosporins). 1 Meropenem breakpoints for Streptococcus pneumoniae and Haemophilus influenzae in meningitis are 0.25 mg/l (Susceptible) and 1 mg/l (Resistant). Buy low price Meropenem Injection Ip 1G in Sadashiv Peth, Pune. Staphylococcus aureus (methicillin-susceptible)£, Staphylococcus species (methicillin-susceptible) including Staphylococcus epidermidis, Streptococcus milleri group (S. anginosus, S. constellatus, and S. intermedius), Peptostreptococcus species (including P. micros, P anaerobius, P. magnus), Species for which acquired resistance may be a problem, $ Species that show natural intermediate susceptibility, £ All methicillin-resistant staphylococci are resistant to meropenem. Hence given the high cost of clinical trials and R&D these branded drugs tend to be priced heavily for the firms to recover the money spent and also to earn windfall profits ( Patent life is only for 20 years for these drugs ). Due to the rapid onset and the extent of the decrease, co-administration of valproic acid/sodium valproate/valpromide with carbapenem agents is not considered to be manageable and therefore should be avoided (see section 4.4). Meropenem Injection 500MG Meropenem is used to treat severe infections of the skin or stomach. 1g . Patients who have a history of hypersensitivity to carbapenems, penicillins or other beta-lactam antibiotics may also be hypersensitive to meropenem. If you get any side effects, talk to your doctor or nurse. 2-8°C) should be used within 1 hour after it has left the refrigerator. In individuals with normal renal function, rapid renal elimination will occur. Meropenem is generally well tolerated by the central nervous system. Meropenem may be used to treat bacterial infection of the blood which might be associated with a type of infection mentioned above. • Keep this leaflet. Due to the rapid onset and the extent of the decrease, co-administration of valproic acid/sodium valproate/valpromide with carbapenem agents is not considered to be manageable and therefore should be avoided (see section 4.4). In this case, the prepared solution if stored under refrigeration (i.e. Renal impairment results in higher plasma AUC and longer half-life for meropenem. Your doctor will tell you how to give, You should normally have your injections at the same times each. The medicinal product is supplied in pack sizes of 1 or 10 vials. Meropenem is licensed for children over 3 months of age. Enterobacteriaceae Pseudomonas aeruginosa or Acinetobacter spp.) Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity (see section 5.3). The maximum daily dose of this product is equivalent to ≥27% of the WHO recommended maximum daily intake for sodium. The maximum recommended daily dose of this medicinal product contains 540 mg sodium (found in table salt). Simultaneous administration of antibiotics with warfarin may augment its anti-coagulant effects. From a microbiological point of view, unless the method of opening/reconstitution/dilution precludes the risk of microbiological contamination, the product should be used immediately. As a precautionary measure, it is preferable to avoid the use of meropenem during pregnancy. Each ml of reconstituted solution contains 50 mg Meropenem. What Meropenem is and what it is used for, What you need to know before you take Meropenem, Contents of the pack and other information. Swelling of the face, lips, tongue or other parts of the. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity (see section 5.3). The following table of pathogens listed is derived from clinical experience and therapeutic guidelines. Hepatic function should be closely monitored during treatment with meropenem due to the risk of hepatic toxicity (hepatic dysfunction with cholestasis and cytolysis) (see section 4.8). Additional considerations for dosing are needed when treating patients with renal insufficiency (see further below). 2 g x 3 daily was taken into consideration for severe infections and in setting the I/R breakpoint. Glanders and melioidosis: Use of meropenem in humans is based on in vitro B.mallei and. Meropenem Injection IP stockiest and super stockiest (distributor) in the field of tablets, syrup, otc, antibiotics, life saving and critical care products. Merokem 1 gm Injection is probably safe to use during breastfeeding. Prescribers are advised to take into account the local prevalence of resistance in these bacteria to penems. varies across the European Union. 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